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August 5, 1944


JAMA. 1944;125(14):977-978. doi:10.1001/jama.1944.02850320035013

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QUINACRINE HYDROCHLORIDE (ATABRINE) FOR MALARIA  On May 31, 1944 the Board for the Coordination of Malarial Studies adopted the following resolution concerning the relative value to the armed forces of quinacrine hydrochloride, U. S. P. (atabrine), quinine and totaquine, U. S. P.On the basis of controlled quantitative studies in civilian, Army and Navy establishments, the evidence at hand justifies the following statement:

  1. In the Suppressive Therapy.—Quinacrine (atabrine) has proved to have all the antimalarial properties ascribed to quinine in the suppression of malaria during and subsequent to exposure to infected mosquitoes. Effective suppression can be accomplished over long periods of time by proper use of quinacrine. Available evidence indicates that this end may be achieved without danger to the individual.

    Earlier reports indicated a significant incidence of gastrointestinal disturbances in certain groups of men receiving suppressive quinacrine therapy. For practical purposes these adverse reactions can be avoided by

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