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September 2, 1944


Author Affiliations

Department of Contagious Diseases, City Hospital, Cleveland.

JAMA. 1944;126(1):49. doi:10.1001/jama.1944.02850360051024

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To the Editor:—  I feel that physicians should be warned against the use of sulfonamide drugs in the treatment of poliomyelitis.It has been noticed clinically that when paralyses of the intestine and urinary bladder persist there are apt to be extensions of the somatic paralyses. When urinary retention was produced in animals (monkeys) by the use of sulfonamide compounds, drugs which produced ureliths and blockage of the ureters, a more massive disease was produced two or three days sooner than that which appeared in controls simultaneously injected with poliomyelitis virus.Rosenow had the same experience with sulfapyridine at the Mayo Clinic and reported that this drug produced an additive neurotoxic effect.Recently an explosive epidemic of poliomyelitis occurred in a small town of northern Ohio. The number of patients that developed severe paralysis seemed out of proportion to the normal expectancy. Most of these patients had received sulfonamide drugs

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