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September 9, 1944


JAMA. 1944;126(2):103-104. doi:10.1001/jama.1944.02850370041013

Fortunately the most frequent clinical form of poliomyelitis is the abortive or nonparalytic. Similar transitory infections may occur in the experimental disease in monkeys. In both cases the absence of paralysis is not necessarily due to failure of the virus to invade and multiply in the tissues of the central nervous system but to limitation of its spread therein. The limitation may depend on the virus, on the host or on both. Faber, Silverberg and Dong1 studied the resistance to a strain of virus of the cynomolgus monkey under well controlled experimental conditions. They found that nontraumatic exposures to the virus of the respiratory and alimentary mucous membranes of cynomolgus monkeys may be followed by a definite resistance to later intracerebral inoculations of the virus. In such cases typical lesions were found in the central nervous system descending from the level of the inoculation into the brain stem and

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