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October 5, 1929

Die Reizkörperbehandlung des Diabetes.

JAMA. 1929;93(14):1089. doi:10.1001/jama.1929.02710140055036

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This is devoted to a new theory for the amelioration of diabetes mellitus, its complications and its sequelae. Dr. Gustav Singer accepts insulin as a life saver in coma or as necessary in the diabetes of childhood. He does not believe that insulin has increased the tolerance of diabetic patients who have used it continuously; in fact, he maintains in some cases it has decreased their dextrose tolerance. Quite by necessity in the early insulin era he was led to use protein injections to raise dextrose tolerance. Later he investigated the subject more thoroughly. By a series of animal experiments and a study of 279 cases, Dr. Singer arrived at the conclusion that a foreign protein, particularly a vegetable protein, when injected subcutaneously in increasing dosage twice weekly but not in sufficient dosage to cause a general reaction such as a rise in temperature and pulse rate, will gradually elevate

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