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October 21, 1944


Author Affiliations


From the Division of Experimental Medicine, Mayo Foundation.

JAMA. 1944;126(8):467-469. doi:10.1001/jama.1944.02850430001001

It has been known for almost a century that the concentration of the sugar in the blood might under certain conditions decrease to a very low value, but it has been only a little more than two decades since it was learned that a characteristic group of symptoms followed by death developed in hypoglycemia and that the administration of suitable amounts of glucose would restore the moribund organism in hypoglycemia to normal. The concomitant development of the characteristic symptoms associated with hypoglycemia and the restoration of the dying organism to a quick and complete recovery by glucose are not only among the most dramatic but also some of the most constant biologic phenomena noted in the higher forms of animals. It is my purpose in this paper to present briefly the current knowledge concerning these two physiologic processes which has been obtained from a review and evaluation of the results

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