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October 28, 1944


Author Affiliations


From the Department of Dermatology, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital.

JAMA. 1944;126(9):544-550. doi:10.1001/jama.1944.02850440016005

We are presenting a report of 332 cases of early syphilis treated in the past three years with massive doses of arsphenamine by the syringe method, the treatment period being five to six days. Arsphenamine 1 was chosen because of our experience in the rapid healing of syphilitic lesions and the spectacular cures we had witnessed with this drug in early syphilis when other arsenicals had failed, and again because of the excellent results we had obtained in the treatment of early syphilis at the Vanderbilt Clinic over a period of some twelve years with this arsenical. Such observations encouraged us to think that some one should evaluate this drug in an intensive treatment program of early syphilis, i. e. the five day treatment.

We were prompted to undertake this study by the encouraging results of Leifer, Chargin and Hyman,2 who treated 382 patients by the intravenous drip method

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