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October 28, 1944


JAMA. 1944;126(9):571. doi:10.1001/jama.1944.82850440012010a

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ISO-PAR.—  A mixture of water insoluble isoparaffinic acids partially neutralized with hydroxybenzyl-dialiphatic amines. The water insoluble isoparaffinic acids are obtained by oxidation of petroleum hydrocarbons by the passage of a current of oxygen under pressure at an elevated temperature in the presence of a metallic catalyst. The water insoluble monocarboxylic and dicarboxylic acids with from 6 to 16 carbon atoms are separated and purified by fractional distillation. The hydroxybenzyl-dialiphatic amines are combined directly with the isoparaffinic acids or in a suitable solvent. The latter is then removed by distillation.

Actions and Uses.—  Unguentum Iso-Par is for external use only. It should not be covered with thick tight bandaging, since irritation may result from this type of dressing. It is said to be of value in the treatment of pruritus ani and vaginae, mycotic infections of the hand and feet and eczemas of the ear and certain skin allergic manifestations. This

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