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December 16, 1944

THE EFFECT OF STARVATION ON DIABETES INSIPIDUS

Author Affiliations

New Haven, Conn.

From the Department of Internal Medicine, Yale University School of Medicine, and the New Haven Hospital.

JAMA. 1944;126(16):1027. doi:10.1001/jama.1944.82850510003008a
Abstract

It has recently been demonstrated by Winter, Sattler and Ingram1 that the polyuria of experimental diabetes insipidus in animals is greatly reduced or eliminated by starvation. The following case illustrates the same phenomenon in a woman with diabetes insipidus complicated by vomiting of pregnancy:

M. H., a woman born Jan. 1, 1918, was admitted to the New Haven Hospital March 15, 1944 for pernicious vomiting of pregnancy. Her last menstrual period had been Dec. 31, 1943. She was reported to have been seriously ill with "acidosis" when 3 to 4 years old but knew no details of the illness. At 16 she was treated with injections for amenorrhea. At 18 she suffered for a full summer with intermittent attacks of headache and vomiting. She was, however, able to return to college in the fall and complete her course. Regular, spontaneous menstruation did notbegin until she was 21 years old.

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