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This little work stems apparently out of the fact that in Costa Rica, in the author's opinion, thyroid dystrophies are due not only to exogenous factors, such as iodine deficiency, but also to endogenous factors. The author believes that special normal physiologic indexes must be established for countries, such as Costa Rica, where climate and other factors influence physiologic functions differently as compared with temperate countries. In studying the etiology of Costa Rican thyroid dystrophies, the author develops a hypothesis advanced in an earlier publication. This hypothesis has to do with the formation of antihormones, and his conclusions fall essentially in line with accepted thought in this connection, so far as the broad principles of antihormone formation are concerned. The author has carried out considerable experimentation on the influence of hormones and antihormones, using serums of various species of animals. As regards human beings, this reaches a focus in the
Investigaciones sobre fisiopatología tiroidea. JAMA. 1944;126(16):1056. doi:10.1001/jama.1944.02850510064026