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December 30, 1944

PENICILLIN FAILURES

Author Affiliations

Michael Reese Hospital, Chicago.

JAMA. 1944;126(18):1167. doi:10.1001/jama.1944.02850530045021

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Abstract

To the Editor:—  We read with great interest the communication of Drs. A. L. Bloomfield, M. M. Kirby and C. D. Armstrong in The Journal, November 11, on "A Study of 'Penicillin Failures.' " Our own experience with subacute bacterial endocarditis supports their conclusion. We have had good results with a series of 10 successive unselected cases in which penicillin alone was given 200,000 to 400,000 units per day for three to nine weeks either continuous intravenously or intramuscularly every hour day and night throughout the entire course of therapy. (The penicillin was provided by the Office of Scientific Research and Development from supplies assigned by the Committee on Medical Research for clinical investigations recommended by the Committee on Chemotherapeutics and Other Agents of the National Research Council.) Seven of these patients have been discharged from the hospital and have been well up to seven months so far; the other 3

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