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January 6, 1945

Latrodectus mactans y latrodectismo: Estudio experimental y clínico

JAMA. 1945;127(1):55. doi:10.1001/jama.1945.02860010057023

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In all probability this is the most comprehensive monograph ever published on spiders of the black widow group. The study was suggested to the author by Dr. B. A. Houssay, in whose laboratory most of its experimental part was carried out. The study is systematic. It starts with the history of latrodectism, zoologic place of Latrodectus and its biology (ecologic data, longevity, habitat, reproduction and so on), which is followed by a chapter by Dr. J. Porto on the structure of the poisonous glands of the insects. Then there is an analysis of what is known on the chemical components of the venom, effects on other animals and pharmacology of the active principles. From the experiments of the author, sometimes duplicating results already known, it results that the poison exerts its effects on the central nervous system with subsequent rise of the blood pressure and changes in the T wave

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