Since ergotamine tartrate has been recommended as a useful drug in the treatment of "battle reaction,"1 it was thought that it might prove valuable in the treatment of "operational fatigue" (war neuroses) in flying personnel returned to this country from combat.
Patients selected for treatment with this drug were those with evidence of sympathetic overactivity, manifested particularly by increased restlessness, tremor, sleeplessness, tension and agitation. The dosage given at first was that recommended by Heath and Powdermaker: 3 mg. for the first dose, then 2 mg. every three hours for ten days. Because of untoward symptoms this dose was quickly modified to 2 mg. every four hours for four doses daily for ten days. All patients in this report were given the latter dosage, except the first 3, who were given the larger dose for the first twenty-four hours only. All were confined to the ward during treatment and were
Grinker RR, Spivey RJ. ERGOTAMINE TARTRATE IN THE TREATMENT OF WAR NEUROSES. JAMA. 1945;127(3):158. doi:10.1001/jama.1945.92860030003007b