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January 20, 1945

PROLONGING THE ACTION OF PENICILLIN

JAMA. 1945;127(3):161-162. doi:10.1001/jama.1945.02860030033011
Abstract

The versatility of American medical research is well illustrated by the announcement of a third successful method of prolonging the therapeutic action of penicillin. Trumper and Hutter1 of the National Naval Medical Center, Bethesda, Md., are credited with this technic.

Earlier investigators2 found that within an hour after intravenous injection of penicillin fully 60 per cent of the injected dose is excreted in the urine. The penicillin titer of the blood stream falls to zero before the end of the second hour. As a result of the evanescent character of this drug, many of the earlier clinical cases failed of cure. In the Bethesda Hospital, of 10 patients with gonorrhea given a single intramuscular injection of 50,000 Oxford units of penicillin only 2 were cured. Two doses of 50,000 units each given at six hour intervals effected a cure in only 55 per cent of the cases.

The

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