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March 10, 1945

PENICILLIN IN THE TREATMENT OF INFANTILE CONGENITAL SYPHILISA BRIEF PRELIMINARY NOTE

Author Affiliations

NEW ORLEANS; PHILADELPHIA; BALTIMORE; GALVESTON, TEXAS

From the Tulane University School of Medicine (Drs. Platou and Hill), the University of Pennsylvania School of Medicine (Dr. Ingraham), the Johns Hopkins University School of Medicine (Dr. Goodwin) and the University of Texas School of Medicine (Drs. Wilkinson and Hansen).

JAMA. 1945;127(10):582. doi:10.1001/jama.1945.02860100026006
Abstract

This is a brief preliminary note, as of Nov. 7, 1944, concerning 69 infants with manifest early congenital syphilis who have been treated with sodium penicillin by the university groups at Baltimore, Philadelphia, Galveston and New Orleans. Penicillin was administered intramuscularly in saline solution every three hours in sixty injections over a seven and one-half day period. Total dosages used ranged from 16,000 to 32,000 Oxford units per kilogram of body weight. No other antisyphilitic treatment was given.

In 34 of these 69 infants reactions occurred during treatment. Nearly all of these reactions were mild, consisting of moderate fever beginning on the first or second day of treatment and seldom lasting longer than three days. One infant, forty-eight hours after treatment was begun, suddenly developed severe, nearly fatal collapse. Three infants died during or soon after treatment (twenty-four hours, seven days and nine days after penicillin was started); all of

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