During the summer and fall of 1943 a very large number of American soldiers stationed in the Far East developed malaria. During the period from the following January until the end of May the incidence of primary attacks of malaria dropped to an almost negligible figure, but patients continued to be admitted in considerable numbers with relapsing tertian malaria. Some of these men had been hospitalized and treated with various standard antimalarial courses five or more times within the preceding few months. Relapsing malaria was a serious menace to the efficiency of the men and their organizations and a burden on the medical installations. An ideal opportunity was presented to observe relapsing tertian malaria during a period in which the confusing factor of reinfection was practically negligible and to test the efficacy of a different form of therapy in this disease.
Intravenous arsenical therapy has been used for
Kay CF. FAILURE OF MAPHARSEN AS AN ADJUVANT TO ATABRINE IN THE TREATMENT OF RELAPSING TERTIAN MALARIA. JAMA. 1945;127(15):984. doi:10.1001/jama.1945.92860150007006a