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December 5, 1936


JAMA. 1936;107(23):1893-1894. doi:10.1001/jama.1936.02770490047016

In the rapid development of our knowledge of the chemistry and physiology of the vitamins, definite chemical structures have already been assigned to a number of them. The symptoms of vitamin deficiencies have been established and in many instances the resulting pathologic condition has been largely clarified. Although the end results of vitamin deprivation are now fully described, the early alterations in the normal physiologic functions of the organism, occurring before gross pathologic changes become manifest, are quite obscure. As in many other studies of intermediary metabolism, the initial and final steps in the process are easier to elucidate than are the transformations that take place in the course of the development of symptoms of deficiency. Investigators are, however, actively looking into these difficult relationships. The studies have already produced data with respect to the possible relationship of vitamin B1 to carbohydrate metabolism in general and, more specifically, to

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