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December 5, 1936

Current Comment

JAMA. 1936;107(23):1894-1895. doi:10.1001/jama.1936.02770490048017

BLOOD PHOSPHATASE IN DIAGNOSIS OF JAUNDICE  The significance of phosphatase in the blood has for some time been a subject of debate. Rothman and his co-workers1 have recently reported a study of the blood phosphatase based on all the cases of jaundice observed by them during the past three years and on a series of cases without jaundice and with none of the other pathologic states believed to influence phosphatase values. The cases of jaundice were classified in the orthodox manner under the heads of obstructive jaundice, hepatocellular or nonobstructive jaundice and hemolytic jaundice. The method of phosphatase determination employed by these investigators was a slight modification of Roberts' method. In many instances the phosphatase determinations were repeated at frequent intervals, and in most instances quantitative serum bilirubin determinations were done simultaneously. The phosphatase values in most of the cases of obstructive jaundice were found to have values of

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