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May 26, 1945

THE LOW AGGLUTININ TITER OF BOTH SMALL AND LARGE POOLS OF PLASMA

Author Affiliations

Associate Technical Director, Blood Donor Service, American Red Cross NEW YORK; Technical Director, Blood Donor Service, American Red Cross MEDICAL CORPS, ARMY OF THE UNITED STATES

From the American Red Cross Blood Donor Service and the Public Health Research Institute of the City of New York, Inc.

JAMA. 1945;128(4):277-279. doi:10.1001/jama.1945.02860210033008
Abstract

It is well known that when plasmas obtained from individuals belonging to the different blood groups are pooled there is evident neutralization of the agglutinins in the pooled plasma. This neutralization of the agglutinins occurs between A and B agglutinogens present in solution in the plasma from groups A, B and AB and the anti-A and anti-B agglutinins from groups O, A and B.

The agglutinin titers in pooled plasma are believed to be sufficiently low so that pooled plasma can be administered intravenously in large amounts to individuals of any blood type without fear of causing serious reactions from possibly incompatible agglutinins. This is borne out by an extensive, worldwide experience by a great number of physicians in the therapeutic intravenous use of pooled plasma.

However, when this investigation was started there were no publications of the determination of the agglutinin titers in large numbers of pools of plasma

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