Generalized leukemic infiltration of the viscera, as well as of the bones, is not uncommon. Frequently it occurs in association with a normal blood picture; i. e., an aleukemic leukemia. The blood picture may change and the characteristic signs of leukemia may appear, but during the aleukemic phase the diagnosis of the nature of the disease is unusually difficult.
Involvement of the gastro-intestinal tract by the various lymphomas—under this broad term Hodgkin's disease, lymphosarcoma, leukemia, aleukemic leukemia and reticulosis may be included—is repeatedly observed at autopsy. From a roentgenologic standpoint, lymphomatous infiltration of the gastro-intestinal tract and more especially of the stomach is of particular interest. The changes produced by this disease in the stomach and upper part of the duodenum are most intriguing because of the difficulty of their recognition during life and the bizarre picture that they present in the roentgenogram. In spite of the many cases of
RIGLER LG. LEUKEMIA OF THE STOMACH PRODUCING HYPERTROPHY OF THE GASTRIC MUCOSA. JAMA. 1936;107(25):2025-2029. doi:10.1001/jama.1936.02770510015004