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This supplement is intended to bring down to date the chapter on "Narcotics of the Fatty Series" of volume 1 of the "Handbuch der experimentellen Pharmakologie." Kochmann summarizes the present status of anesthetics as follows: Chloroform, on account of its intrinsic dangers, is being largely abandoned. Ether is preferred, but not by itself. It is used in combination with other narcotics ("mixed narcotics"). "Prenarcosis" is the term to be applied to the use of a narcotic to make easier the induction of anesthesia, while a "basis narcotic" is one that carries the main burden of an anesthesia, to be completed by a more controllable anesthetic. Kochmann believes that ether as well as local anesthesia is likely to become largely displaced by the gases and by briefly acting intravenous anesthetics. There are intrinsic reasons why the gas anesthetics are safer than ether or chloroform. The latter must be administered at the
Handbuch der experimentellen Pharmakologie. JAMA. 1936;107(25):2077. doi:10.1001/jama.1936.02770510067028