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June 16, 1945

"CHRONIC TOXICITY OF ERGOT"

JAMA. 1945;128(7):539-540. doi:10.1001/jama.1945.02860240065025

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Abstract

To the Editor:—  In your editorial of April 21 on "Chronic Toxicity of Ergot" you state that "there has been no thorough investigation of the chronic effects of ergot in laboratory animals." The paper by Fitzhugh, Nelson and Calvery (J. Pharmacol. & Exper. Therap.82:364 [Dec.] 1944) which you quote at length referred only to my first communication in the American Journal of Pathology (6:299 [May] 1930). I have published additional observations on experimental chronic ergot poisoning in the Archives of Internal Medicine (47:548 [April] 1931) and in the Archives of Surgery (25:1135 [Dec.] 1932). Although my first paper described the morbid anatomy of experimental ergot poisoning in 28 roosters, Fitzhugh and his collaborators quote only my observations on 2 animals. These I submitted at length only because the lesions were most typical. In my experiments I obtained lesions of the vessels, particularly of the comb,

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