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June 16, 1945

The Reticulo-Endothelial System in Sulfonamide Activity

JAMA. 1945;128(7):551. doi:10.1001/jama.1945.02860240077035

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This interesting monograph was presented in 1941 as a dissertation for the degree of doctor of philosophy in pharmacology in the Graduate School of the University of Illinois. It is an important contribution to the role of "defense mechanisms" in chemotherapy. The "defense mechanisms" of the body against bacterial infection depend in part on the activity of the reticuloendothelial system. The many careful experiments reported in this study show that blocking the reticuloendothelial system (by thorotrast) reduces the resistance of animals to infection with Staphylococcus aureus, depresses conjugation of sulfanilamide and sulfathiazole and reduces the chemotherapeutic effectiveness of sulfathiazole in animals infected with Staphylococcus aureus. It is therefore concluded that reticuloendothelial activity is necessary to effective sulfonamide chemotherapy. The large bibliography of six hundred and twelve references refers chiefly to bacterial infections and the sulfonamides. The illustrations offer evidence of the successful blocking of the reticuloendothelial system by means of

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