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December 26, 1936

RESPIRATORY IRRITANTS: THEIR EFFECTS AND PREVENTION

JAMA. 1936;107(26):2134-2135. doi:10.1001/jama.1936.02770520036012
Abstract

Little has been written on the influence of soot on the development of tumors of the lungs. The concentration of coal smoke in most of the large cities in this country, however, is such that it is important to determine the effects of this daily contamination of the inspired air. Seelig and Benignus1 have reported an experimental study dealing with the carcinogenic power of soot on the lungs. They endeavored to determine whether or not the soot deposited out of coal smoke played a part in the development of tumors of the lung in white mice. The soot used in the experiments was secured by sweeping the flue of a hospital furnace that burned Kentucky bituminous nut coal, and it was substituted for sawdust and shavings as a bedding material for the mice. Dust from the soot was raised by the normal activity of the mice, but in addition

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