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December 26, 1936

The Therapeutic Agents of the Pyrrole and Pyridine Group Including the Tropinol, Scopoline, Ecgonine, and Granatoline Derivatives. The Relation Between Their Chemical Constitution and Pharmacologic Action

JAMA. 1936;107(26):2157. doi:10.1001/jama.1936.02770520059033

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This volume is a real contribution to scientific literature because it represents a collection of chemical and pharmacologic data on several series of nitrogen-containing organic compounds. The subtitle on the fly leaf indicates that the volume discusses "The Relation Between Their Chemical Constitution and Pharmacologic Action." Unfortunately, this is not the case. In the last paragraph the author indicates that he recognizes no such relationship, but he suggests that the relationship may be established when a greater fund of knowledge of physicochemical properties and reactions is at hand.

The chemistry consists in giving the names of the compounds according to Chemical Abstracts nomenclature, portraying the structural formulas, which are given in great effusion and without arguments for or against, and for some compounds a few physical properties. Methods of isolation and preparation are not given. The volume would be more valuable to the chemist if the chemical data were more

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