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January 23, 1937

LIVER DEATH A HEPATORENAL SYNDROME

JAMA. 1937;108(4):301-302. doi:10.1001/jama.1937.02780040051014
Abstract

The close association of the liver and the kidneys in the performance of certain metabolic processes dealing with detoxification of various substances by the former and their excretion by the latter suggests a definite interdependence. Disease states of the liver may cause pathologic alterations in the kidneys. Bartlett1 has described renal complications in infectious diseases of the bile passages. Clairmont, von Haberer, Staeheli, Kehr and others have described cases in which anuria followed cholecystectomy or an operation for the relief of obstructive jaundice. They believe that the anuria is caused by a reflex spasm of the renal vessels and that the origin of the reflex is the damaged liver. This is supported by the histologic determination of contracted capillaries of the glomeruli and of the afferent renal vessels.

Among the hepatic diseases that lead to secondary renal involvement, so-called liver death has come to occupy a prominent position. This

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