Prior to the report of Stokes and Neefe1 indicating the value of gamma globulin from pooled human plasma in the prevention and attenuation of infectious (epidemic) hepatitis, no method of control of outbreaks of this disease had been available. The extensive literature on infectious (epidemic) hepatitis that has accumulated in the past several years bears witness to the widespread occurrence of this disease both in the armed services and among civilian populations. The lengthy period of convalescence following infectious hepatitis has made it of prime importance to the armed services of all the United Nations.
On the basis of the report of Stokes and Neefe and on the recommendation of the Surgeon General, U. S. Army, and at the invitation of the Chief Surgeon and the Commanding General, Mediterranean Theater of Operations, U. S. Army, to two of the authors of this present report, field studies on the effectiveness
GELLIS SS, STOKES J, BROTHER GM, HALL WM, GILMORE HR, BEYER E, MORRISSEY RA. THE USE OF HUMAN IMMUNE SERUM GLOBULIN (GAMMA GLOBULIN)IN INFECTIOUS (EPIDEMIC) HEPATITIS IN THE MEDITERRANEAN THEATER OF OPERATIONS I. STUDIES ON PROPHYLAXIS IN TWO EPIDEMICS OF INFECTIOUS HEPATITIS. JAMA. 1945;128(15):1062-1063. doi:10.1001/jama.1945.02860320004002