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August 18, 1945

A MEANS OF INDUCING OLIGURESIS DURING PENICILLIN ADMINISTRATION

Author Affiliations

Louisville, Ky.; Surgeon (R), U. S. Public Health Service, detached to the U. S. Coast Guard with the rank of Lieutenant Commander

JAMA. 1945;128(16):1161. doi:10.1001/jama.1945.92860330003008a
Abstract

In reference to the published material suggesting the advisability of urine concentration in the penicillin therapy of gonorrhea, the following suggestion is made: Pitressin to accomplish this end was suggested to me during observations on pitressin and its influence on human urine secretion. Because of the paucity of clinical material and facilities at sea the suggestion is passed on for evaluation by those more favorably situated for such study.

The antidiuretic principle of posterior pituitary was first noted by von den Velden1 in 1913.

Gargle, Gilligan and Blumgart2 in 1928 showed that it was the pressor function of the posterior pituitary that was responsible for the hormone's antidiuretic principle.

Leberman3 in 1930 made use of this fact by employing the hormone to produce urinary concentration in the execution of renal concentration tests.

McQuarrie and his associates4 in 1936 used the period of diuresis which follows prolonged antidiuresis with pituitary

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