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February 13, 1937

Undersøgelser over spæde Børns Ventrikelsekret, med særlight Henblik paa Pepsin-Løbeproblemet

JAMA. 1937;108(7):583. doi:10.1001/jama.1937.02780070067028

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The purpose of this work was chiefly to study the secretion of pepsin and rennin from the infant's stomach and to find out whether there was any evidence of the presence of rennin as an independent enzyme, different from pepsin. The study was carried out on infants from 8 to 40 weeks old, mostly convalescents in good condition. The gastric content was obtained by giving a test meal consisting of weak tea sweetened with saccharin. The meal was given in amounts adapted to the age of the infant, after a fast of at least six hours. The gastric content was obtained by aspiration forty minutes after the beginning of the meal. For the determination of peptic activity the amino nitrogen was determined at 0 and 120 minutes by the method of Linderstrom-Lang. There was some evidence of increasing peptic activity as the infants grew older; in infants less than 21

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