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September 8, 1945

SEDATION AS AN UNEXPECTED SYSTEMIC EFFECT OF PRIVINE

Author Affiliations

Charleston, S. C.

From the Department of Pediatrics, Medical College of the State of South Carolina.

JAMA. 1945;129(2):129. doi:10.1001/jama.1945.92860360001008
Abstract

Three cases are reported in which privine hydrochloride produced sedation. This effect might not have been anticipated from the general character of the drug, which gives a complicated type of systemic stimulation in animals. Trial observations by Drs. F. M. Martin and R. P. Walton in the Department of Pharmacology disclosed that intravenous doses in 4 rats and 3 dogs produced hyperpnea, gross muscle spasms, occasional reflex hyperexcitability and convulsions. The effects of fatal doses suggestively resembled acute epinephrine deaths.

The clinical observations have a parallel in the systemic actions of ephedrine, which is ordinarily a stimulant or analeptic drug in adults. In a report by Bonzanigo1 ephedrine was found to produce sedative effects frequently in children between the ages of 3 months and 14 years. Ephedrine was given to these patients in doses large enough to produce the characteristic hypertension.

Case 1.  —A girl aged 7 years, with vasomotor rhinitis

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