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February 20, 1937

Straalegenetik og klinisk Røntgenvirksomhed

JAMA. 1937;108(8):670. doi:10.1001/jama.1937.02780080064037

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Abstract

Shortly after the introduction of x-rays into clinical practice, it was observed that the cells of reproduction were especially sensitive to irradiation. This has led some observers to feel that children born from cells damaged by irradiation would show various developmental defects. This is the problem that the author has been working on experimentally. His work was done on white mice. They were subjected to small doses of x-rays up to doses of 800 roentgens, after it had been determined that the sterilization dose was 1,000 roentgens. Some of the animals were subjected to direct irradiation, while some had only scattered irradiation, such as obtains when the animal is in the treatment cubicle but is not in the radiation beam. The author was unable to demonstrate any gene or chromatin effects in his material, but he did find profound effects on growth and longevity of the offspring. As a result

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