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To the Editor—
One sentence in the leading editorial in The Journal, January 2, might suggest that my colleagues and I were the first to investigate the protective action of p-amino-benzenesulfonamide in streptococcic infections of mice. I should much appreciate it if you would allow me to point out that J. and Mme. Tréfouël, F. Nitti and D. Bovet (Compt, rend. Soc. de biol.120:756 [No. 36] 1935) were the first to show the activity of this substance in streptococcic infections. We were able to confirm their work, and we further showed that the sulfonamide treatment of mice infected with hemolytic streptococci and meningococci (see also Proom, Lancet1:16 [Jan. 2] 1937) was more effective than that with the original prontosil.
Buttle GAH. CHEMOTHERAPY IN STREPTOCOCCIC INFECTIONS. JAMA. 1937;108(9):747. doi:10.1001/jama.1937.02780090059025