In January 1945 Stokes and Neefe1 published the first report of the use of human gamma globulin in the prevention of infectious hepatitis. Results indicated that this prophylactic measure was effective and that the use of this substance in infectious hepatitis compared favorably with its use in measles.
In the present report it is our purpose to describe another instance of the effective use of gamma globulin as a prophylactic measure in an institutional epidemic of infectious hepatitis. The outbreak to be described occurred in a Catholic home for children in New Haven.2 This home had on Jan. 20, 1945 a population of 299 children (90 per cent of whom were between the ages of 6 and 16) and 39 adults. During the period between Nov. 5, 1944 and April 27, 1945, 53 cases of infectious hepatitis with jaundice and 56 cases of questionable hepatitis without clinical jaundice
HAVENS WP, PAUL JR. PREVENTION OF INFECTIOUS HEPATITIS WITH GAMMA GLOBULIN. JAMA. 1945;129(4):270–272. doi:10.1001/jama.1945.02860380028008