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March 13, 1937

HODGKIN'S DISEASE WITH LEUKOPENIA

Author Affiliations

Duluth, Minn.

JAMA. 1937;108(11):876-879. doi:10.1001/jama.1937.92780110001008
Abstract

The blood picture in Hodgkin's disease has been of great interest and a subject for controversy since Bunting1 published his classic work on this subject over two decades ago. Bunting postulated two constant features in the blood count: "an increase in blood platelets and an absolute increase in transitional cells." Furthermore, he stated that "in early cases there is a transitory increase in lymphocytes and basophils with a deficiency in eosinophils and a normal or low neutrophil percentage which is followed by a gradual decrease in lymphocytes and an increase in eosinophils. In late cases there existed a marked neutrophilic leukocytosis with a diminution in white cell elements other than in those cells and the transitionals." In the early cases of one year or less in duration he found that there was a normal or slightly diminished total while blood cell count and in those of longer duration a moderate or

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