Our purpose in this article is to evaluate the role of penicillin in the treatment and control of gonorrhea. Our results do not justify the prevailing optimism held by the public and many of the medical profession as to the efficacy of penicillin as an easy, infallible cure of gonorrhea. Some investigators have reported from 95 to 100 per cent cures with varying doses of penicillin.1 The full benefits of penicillin therapy are not achieved unless a careful search is made for patients who still harbor the disease. Penicillin will cure most cases of gonorrhea, but cure is not necessarily accomplished by the first course of the drug or by penicillin alone. Supportive treatment such as pyrotherapy and the sulfonamides is necessary at times even with repeated courses of penicillin. It is in the interest of public health that the limitations of the drug should be well understood.
KOCH RA, HAINES JS, HOLLINGSWORTH WY. EVALUATION OF PENICILLIN IN GONORRHEA TREATMENT AND CONTROL. JAMA. 1945;129(7):491–495. doi:10.1001/jama.1945.02860410007002