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October 13, 1945


Author Affiliations

Chief, Division of Venereal Diseases, City and County of San Francisco Department of Public Health; P. A. Surgeon, U. S. Public Health Service; Chief of Genitourinary and Venereal Disease Services, United States Marine Hospital, San Francisco; Medical Director, United States Public Health Service; Medical Officer in Charge, United States Marine Hospital, San Francisco SAN FRANCISCO

JAMA. 1945;129(7):491-495. doi:10.1001/jama.1945.02860410007002

Our purpose in this article is to evaluate the role of penicillin in the treatment and control of gonorrhea. Our results do not justify the prevailing optimism held by the public and many of the medical profession as to the efficacy of penicillin as an easy, infallible cure of gonorrhea. Some investigators have reported from 95 to 100 per cent cures with varying doses of penicillin.1 The full benefits of penicillin therapy are not achieved unless a careful search is made for patients who still harbor the disease. Penicillin will cure most cases of gonorrhea, but cure is not necessarily accomplished by the first course of the drug or by penicillin alone. Supportive treatment such as pyrotherapy and the sulfonamides is necessary at times even with repeated courses of penicillin. It is in the interest of public health that the limitations of the drug should be well understood.


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