Several reports1 have appeared dealing with the use of the penicillin salts in the treatment of early syphilis, benign late, early and late congenital syphilis and neurosyphilis since the original report of Mahoney, Arnold and Harris2 in June 1943. Thus far there have been no available reports concerning the use of penicillin in cardiovascular syphilis.
Recently we have had occasion to study the effect of penicillin therapy on 2 patients with syphilitic aortitis and were forced to discontinue therapy in both because of the untoward effects noted. The present report seems in order because of the widespread interest in and the increasing usage of penicillin in the therapy of syphilis.
REPORT OF CASES
—R. C, a white man aged 56, came under our observation in December 1941, at which time he was admitted to the hospital because of cough and dyspnea associated with the
Dolkart RE, Schwemlein GX. THE TREATMENT OF CARDIOVASCULAR SYPHILIS WITH PENICILLIN. JAMA. 1945;129(7):515–516. doi:10.1001/jama.1945.92860410002009a