Chronic, stubborn, nonhealing ulcers of the leg constitute one of the most annoying conditions that the profession is called on to treat. A superficial ulcer often develops into a deep one involving the subcutaneous tissues and even resulting in a periostitis of the underlying bone. The usual accepted treatment for this type of ulcer has included rest in bed, wet dressings, various ointments and lotions, skin grafts, excision of necrotic areas, adhesive strapping over ulcerated areas, and injection of varicose veins.
These traditional approaches to healing, however, have in many cases been unsatisfactory and have failed often to effect a cure. In view of the fact that there is not, as yet, a satisfactory specified method of treating these stubborn and nonhealing wounds, I am suggesting the use of allantoin.
Allantoin has been found to have the same effects on surgical wounds as maggots; namely, the removal of infected material
KAPLAN T. THE ALLANTOIN TREATMENT OF ULCERS. JAMA. 1937;108(12):968-969. doi:10.1001/jama.1937.02780120038010