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November 3, 1945

INTRACELLULAR ANTIBODIES

JAMA. 1945;129(10):678-679. doi:10.1001/jama.1945.02860440026011
Abstract

In 1913 Much,1 Manwaring2 and others reported experimental evidence which led them to propose a tentative theory of "partial antibodies" to account for the phenomena of acquired immunity to tuberculosis. Specific agglutinins, precipitins and other so-called antibodies are found in the circulating blood; the theory assumed that the really essential bactericidal factors are found only in the fixed tissue cells. In support of this theory it was shown2 that tubercle bacilli, while rapidly lysed in the peritoneal cavities of tuberculous animals, are not lysed in the animal's serum. Manwaring found that the acquired power of intraperitoneal lysis of tubercle bacilli cannot be transferred to normal animals even by total blood transfusion. The essential specific bacteriolysins present in the immunized peritoneal cells apparently are not given off in detectable amounts into the blood stream; or, if given off, they presumably are destroyed or otherwise rendered inactive in much

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