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April 3, 1937

Experimental Studies on a Transmissible Myelomatosis (Reticulosis) in Mice

JAMA. 1937;108(14):1209. doi:10.1001/jama.1937.02780140065037

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Abstract

The fact that leukemia occurs in mice was observed by Eberth in 1878. Since that time there have been numerous studies of leukemia, lymphosarcoma and leukosarcoma in the smaller laboratory animals. Of late it has been found that lymphatic and myeloid leukemia can be transmitted by inoculation in inbred strains of mice but is possible only with living cells and in the author's experiments mainly in animals that were previously irradiated. The conclusion has been drawn by Furth and others from their studies that lymphomatosis and also myelosis represent a neoplastic process. The author, while he surveys fully the conclusions of others, has confined his own observations to a leukemic disease in which myeloblasts are abundant in the blood, a myelomatosis in contrast to Furth's myelosis, in which myelocytes predominate. The pathologic changes in the blood and organs of the mice with myelomatosis were carefully studied. Curiously the spleen is

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