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November 17, 1945

FAILURE OF CHOLINE CHLORIDE TO AUGMENT ANEMIA IN CIRRHOSIS OF THELIVER

Author Affiliations

Boston

Dr. Watson is Commonwealth Fund Fellow.

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School.

JAMA. 1945;129(12):802-803. doi:10.1001/jama.1945.92860460002007a
Abstract

The report by Davis1 of the production of hyperchromic anemia in dogs by the administration of choline chloride is of considerable interest in view of the increasing use of this substance in the treatment of liver disease in man.2 Cartwright and Wintrobe3 recently gave choline chloride to 3 men over a period of ninety days without any hematologic effect. However, since none of their patients was suffering from hepatic disease, it seems worth while to report briefly a hematologic study of the effect of choline in a patient with cirrhosis of the liver and macrocytic anemia.

Davis1 produced anemia in dogs by giving choline chloride orally in a dose of 10 mg. per kilogram of body weight daily for at least twenty-five days. When a definite anemia was established, the dosage was successively increased to 20 and 30 mg. per kilogram. There was said to be a

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