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To the Editor:—
The emphasis which Lieutenant Pijoan and I intended to place in our paper was on the vehicle and its convenience, not on the incorporated sulfathiazole. Sulfadiazine in dimethoxy cellulose was used without alcohol in an aqueous medium for the treatment of impetigo (Southwest. Med.27:118 [May] 1943) and in the treatment of burns and other infections (Bull. Johns Hopkins Hosp.69:217 [Aug.] 1941; 71:304 [Nov.] 1942). In these reports the dimethoxy cellulose was dissolved in water and not in alcohol. The introduction of alcohol was not for its therapeutic action but rather to increase the drying rate, a practical point in convenience. However, dimethoxy cellulose apparently did limit the spread of the infection. In this light the conclusion which we expressed may be considered as not well worded.
Draeger RH. SULFATHIAZOLE IN PLASTIC VEHICLE-Reply. JAMA. 1945;129(12):825. doi:10.1001/jama.1945.02860460049023