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December 1, 1945

THE DEVELOPMENT AND USE OF ALPHA-NAPHTHYL THIOUREA (ANTU) AS A RAT POISON

Author Affiliations

BALTIMORE

From the Psychobiological Laboratory, Phipps Psychiatric Clinic, the Johns Hopkins Hospital.

JAMA. 1945;129(14):927-931. doi:10.1001/jama.1945.02860480007002
Abstract

During the past three years an investigation has been carried on in this laboratory with the purpose of finding and developing a new rat poison. The best poison so found, alpha-naphthyl thiourea (ANTU), has been proved through extensive laboratory tests and also by controlled field trials in a large city to be an effective and specific poison for the Norway rat, a very common and destructive rat throughout the world.

Since secrecy restrictions on this work have now been lifted and the Office of Scientific Research and Development has given permission for the manufacture and release of alpha-naphthyl thiourea to the public, it seems advisable to present an account of the development of this poison together with effective ways of using it, its toxicity to animals other than rats and procedures to be followed in case of accidental poisoning. The experience gained by large scale field use of alphanaphthyl thiourea

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