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Relapsing fever in the United States is a sporadic disease, and seldom does the opportunity present itself to study the clinical manifestations and therapeutic problems which arise in a significant number of cases. During August and September 1944 and April and May 1945, 11 proved cases of relapsing fever were observed and treated at an army hospital in Texas. These 11 cases demonstrated several interesting and important features from a diagnostic and therapeutic standpoint. Among these features to be discussed in detail are (1) the difficulties in diagnosis, (2) the high incidence of neurologic involvement and (3) the ineffectiveness of the accepted treatment in contrast to the striking response obtained with newer methods of therapy.
GENERAL CLINICAL PICTURE
Six patients entered the hospital with an admission diagnosis of "nasopharyngitis"; 3 had diagnoses of "hyperpyrexia," "recurrent malaria" and "headache and nausea," 1 entered the surgical service with cellulitis of his left
TAFT WC, PIKE JB. RELAPSING FEVERREPORT OF A SPORADIC OUTBREAK, INCLUDING TREATMENT WITH PENICILLIN. JAMA. 1945;129(15):1002–1005. doi:10.1001/jama.1945.02860490014004