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April 17, 1937

Veröffentlichungen aus der Konstitutions- und Wehrpathologie

JAMA. 1937;108(16):1370-1371. doi:10.1001/jama.1937.02780160062038

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This monograph on renal dwarfism develops the subject from the standpoint of previous cases described in the literature with especial emphasis on the clinical picture, the pathologic anatomy and the pathologic physiology. Two cases studied by the author are carefully described. Eighty-six references are given. The author goes into great detail with regard to the relationship of the bone changes of so-called renal rickets. He also discusses the significance of blood chemistry with particular emphasis on the changed calcium: phosphorus ratio. He concludes that the dwarfism is due in all probability to the development of growth-restraining substances arising in the body because of the increasing acidosis and toxicosis resulting from so-called chronic interstitial nephritis. He suggests the possibility that in this process certain hormones are destroyed.

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