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May 1, 1937

Sérothérapie antipoliomyélitique d'origine animale (S. A. P.). (Seize années d'expérimentation clinique.)

JAMA. 1937;108(18):1566. doi:10.1001/jama.1937.02780180090031

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This is an account of the experiences in the laboratory and with the treatment of patients with acute anterior poliomyelitis by three types of animal serums produced by the author. A brief survey is given of the experimental background for the production of these serums. This is followed by a detailed account of the method of testing of the serums and their actual production in three hosts: a species of lower monkey, the chimpanzee and the horse. Concentration of these serums was practicable by a modification of Ramon's method for the concentration of pseudoglobulin, the antiviral activity being increased twentyfold. The last two thirds of the booklet is given to case reports, in the majority of which the serum (of one origin or another, mainly antiviral horse serum) was administered after the onset of paralysis. These reports taken individually or as a whole might well be compatible with the natural

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