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May 22, 1937

Current Comment

JAMA. 1937;108(21):1804-1805. doi:10.1001/jama.1937.02780210044018

ROENTGEN IRRADIATION OF THE OVARIES IN MAMMARY CANCER  The existence of a relationship between the secretion of the ovaries and the growth and development of the mammary glands has been well established, both in man and in experimental animals. In man, this relationship is evident in the development of the breasts at puberty and subsequently in the rhythmic changes of the mammary gland during the menstrual cycle. That these changes are brought about chiefly by estrogen, secreted by the ovary, has been adequately demonstrated. Because of the growth promoting action of this factor on the mammary gland and because of the relatively high incidence of carcinoma of the breast during the period of greatest ovarian activity, many investigators have long suspected that there might exist a causal relationship between estrogen and mammary cancer. A considerable amount of recent experimental work appears to support such a view. For example, a number

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