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June 5, 1937

"MACHINE FEVER" IN SYPHILIS

Author Affiliations

Dayton, Ohio. Director, Kettering Institute for Medical Research, Miami Valley Hospital.

JAMA. 1937;108(23):1988. doi:10.1001/jama.1937.02780230048021

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Abstract

To the Editor:—  In the May issue of the Reader's Digest is a condensation of an article entitled "Machine Fever," by Paul de Kruif, which appeared originally in the Country Gentleman for April. The condensed article in the Reader's Digest contains one sentence at the beginning of the second paragraph on page 109 which reads "No longer, then, need a victim of early syphilis come once a week for almost two years for treatment with the standard arsenic and bismuth dosage." I must confess that I am disturbed by the implications of this detached sentence, particularly since it bears on certain experimental studies which we have carried out at the Kettering Institute for Medical Research in Dayton.In the original article by de Kruif, he described accurately and in some detail the character and extent of the experimental studies on the treatment of early syphilis with artificial fever therapy combined

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