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February 20, 1932


JAMA. 1932;98(8):653-654. doi:10.1001/jama.1932.02730340061022

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A New Antidiphtheritic Serum  Dr. Marquézy has presented to the Academy of Medicine a new antidiphtheritic serum, which possesses curative properties superior to those of the existing serums. The new serum is prepared by injecting into horses a mixture of diphtheria toxin and antitoxic serum. The injections are made subcutaneously over a period of several weeks, the antitoxin at first predominating but then gradually diminishing and giving way to the pure toxin. The toxin utilized is derived simultaneously from strain 8 of Park and Williams and from bacilli isolated from the throats of subjects affected with malignant diphtheria. The serum is prepared not solely from the diphtheria toxin but also from living micro-organisms that are injected into the horse along with the toxin. It is therefore both antitoxic and antimicrobic. Before it is used on man, it is deprived of its proteins and then concentrated by means of the physicochemical

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