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June 12, 1937

Pathologie der Functionen und Regulationen

JAMA. 1937;108(24):2069. doi:10.1001/jama.1937.02780240061034

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This embraces not only recent advances in medicine but a point of view developed by the author which is provocative and enlightening. His main thesis is that there exists a neuro-hormonal regulatory mechanism in the diencephalic hypophysial region which governs function generally. A pointed example is the thyroid gland. Normally the vegetative center in the diencephalon activates the formation of thyrotropic hormone in the hypophysis, which in turn stimulates the thyroid gland to the formation of thyroxine. The latter acts on the diencephalic center in a negative way, preventing overstimulation of the hypophysis until an equilibrium is established. Thus the pathogenesis of disease as well as the other diseases discussed must be considered in a new light, as should the methods of treatment. Similarly the author takes up the various diseases as affecting systems rather than a single organ. In addition to his discussion of the glands of internal secretion

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