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June 26, 1937


JAMA. 1937;108(26):2206. doi:10.1001/jama.1937.02780260034014

Much of the present-day commercial exploitation of vitamins and vitamin-rich foods is based on a belief that excessive intakes will increase the resistance of normal persons to microbic infections. Abundant experimental evidence supports the view that prolonged vitamin deficiencies do decrease antimicrobic resistance, but the data regarding the immunologic effects of superabundant vitamins are inadequate. An experimental study of the possible immunologic benefits of superfluous vitamin C has been reported by Heise and Martin 1 of the Trudeau Sanatorium.

Fifteen normal guinea-pigs were fed a stock ration consisting of carrots, hay, lettuce and oats. Five animals were used as controls and were not given additional vitamins. The other ten were given each a daily intra-abdominal injection of 20 mg. of crystalline cevitamic acid in the form of a neutral salt. After a seven day period, both control and vitamin-treated animals were injected with 300,000 tubercle bacilli into the groin. The

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