During the past two years we have treated forty-five cases of Sydenham's chorea with the Kettering hypertherm.1 This study was initiated during the winter of 1935 and is still in progress at the Fever Therapy Department of the University of Colorado. Previously we reported2 excellent results in thirteen cases, and we have included this group in our present series.
The history of pyretotherapy in chorea dates to von Kern's3 intramuscular injections of milk in 1923. Mas de Ayala4 in 1930 was successful in the treatment of chorea by the artificial induction of relapsing fever. The good results of Roeder5 and others6 with phenylethylhydantoin in the treatment of this disease appeared to be associated with the production of fever. In 1931 Sutton7 first called attention to the triple typhoid vaccine method of inducing fever in chorea. Later Sutton and Dodge8 reported satisfactory results
BARNACLE CH, EWALT JR, EBAUGH FG. ARTIFICIAL FEVER TREATMENT OF CHOREAA TWO YEAR STUDY. JAMA. 1937;109(2):111–113. doi:10.1001/jama.1937.02780280017004